The project
The aim of this project is to generate new insight into the regulation and function of a newfound immunometabolite in macrophages. To do so, you will integrate functional and omics data to define new immunometabolic regulators controlling macrophage responses. Subsequently, new targets will be validated in mouse models and clinical samples. You will use high-end techniques including metabolomics and RNA-sequencing, multi-dimensional cytometry and imaging, and will apply bioinformatics to analyse complex data.

About your role
The successful applicant will join Jan Van den Bossche’s young and enthusiastic research team that is strongly embedded in a department headed by Professor Yvette van Kooyk and collaborate with different local and international partners.

This fundamental project aims to understand the regulation and molecular mechanisms by which immunometabolites control inflammation and macrophage activation.

Depending on the candidate’s interest and expertise, parallel and future projects that translate the obtained knowledge to distinct disease settings can be designed.

The Post-Doctoral researcher will support PhD and undergraduate students in the lab, present at both national and international meetings and publish in leading international journals.

We are looking for a highly-motived candidate with a strong background in immunology, (immune)metabolism and/or a passion for macrophages with the following expertise:

• Obtained PhD in immunology, molecular biology or equivalent;
• Experience with immunological, metabolism and/or molecular biological techniques;
• Expertise with bioinformatics to analyze high-dimensional and omics data is desirable;
• A good track record and scientific curiosity is preferred;
• While you work independently, you are also an valuable team member and have the social skills to collaborate;
• You are enthusiastic, flexible and accurate in your work, and willing to join an interdisciplinary and international environment.

Fixed-term contract: 1 year that will be extended for 3 years after successful evaluation.

• We offer a contract for 1 year that will be extended for 3 years after successful evaluation.
• In addition to a good basic salary, we offer 8.3% end-of-year bonus and 8% holiday allowance. Do you want to know what you will earn? Then calculate your net salary here (subject to change).
• Your pension is accrued with the ABP; VUmc contributes a large part of the premium (70%).
• In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs) and also we offer a bicycle arrangement.
• Free and unlimited access to our online learning environment GoodHabitz.
• An active staff association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and events.
• For an overview of all our other terms of employment, see https://www.werkenbijvumc.nl/watwijbieden/

Amsterdam UMC has an open culture. This means that we hope that everyone feels welcome in our organization and that we strive to offer equal opportunities to everyone. We therefore cordially invite all interested parties to respond to this vacancy.

For more information about our terms of employment, please visit our website.

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Amsterdam UMC

Working at Amsterdam UMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow!

IMMUNOMETLAB

IMMUNOMETLAB at Amsterdam UMC is seeking a highly driven Post-Doctoral researcher for an NWO-funded research project. Within the Department of Molecular Cell Biology and Immunology in the vibrant O|2 Lab Building at VUmc, the group led by Dr. ir. Jan Van den Bossche investigates how cellular metabolism impacts on macrophage function and disease outcome. Our team uses an multidisciplinary approach combining experimental techniques such as metabolic and functional cellular analyses, genetic and pharmacological metabolic interventions, metabolomics and transcriptomics, high-end cytometry and imaging in in vivo disease models and patient material.